George Xuezhi Guo earned his Ph.D. in foreign affairs from the University of Virginia in 1999. He spent a year as a national research fellow in Miller Center before becoming an Associate Professor at Guilford College in August 2002.

The courses he teaches include Comparative Politics, Comparative Countries, Leadership Across Cultures, Asia and the World, Chinese Politics, Challenges of Global Democratization, and Theories and Methods in International Studies. During his employment at Guilford, he has been a research fellow in Weatherhead East Asian Institute at Columbia University and a senior research fellow in East Asian Institute at National University of Singapore and has been awarded the library research grants from Harvard University, Duke University, and University of Chicago.  

His articles and book chapters have appeared in many books and prestigious international journals, such as The China Quarterly and The China Journal. He is the author of The Ideal Chinese Political Leader: A Historical and Cultural Perspective (Praeger, 2001), China's Security State: Philosophy, Evolution, and Politics (Cambridge University Press, 2012), and The Politics of the Core Leader in China: Culture, Institution, Legitimacy, and Power (Cambridge University Press, 2019).